Synthesis and characterization of carboxymethyl chitosan hydrogel: Application as site specific delivery for lercanidipine hydrochloride
✍ Scribed by SUBHASH S VAGHANI, MADHABHAI M PATEL, C S SATISH…
- Book ID
- 120899873
- Publisher
- Springer-Verlag
- Year
- 2012
- Tongue
- English
- Weight
- 500 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0250-4707
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The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated
## Abstract pH‐sensitive hydrogels were prepared from poly(ethylene glycol) (PEG) and acrylic acid (AAc) in aqueous solution employing γ‐radiation‐induced copolymerization and crosslinking. The swelling behavior of the prepared hydrogels was determined by investigating the time and pH‐dependent swe