Synthesis and characterization of chitosan hydrogels containing 5-aminosalicylic acid nanopendents for colon: Specific drug delivery
✍ Scribed by Mohammad Reza Saboktakin; Roya M. Tabatabaie; Abel Maharramov; Mohammad Ali Ramazanov
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 149 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The main aim of this research was to develop and evaluate a multiparticulate system of Ac-poly(amidoamine)(PAMAM)(G4)-chitosan (CS) hydrogels exploiting pH-sensitive and specific biodegradability properties for colon-targeted delivery of 5-aminosalicylic acid (5-ASA). All formulations were evaluated for particle size, encapsulation efficiency, swellability, and in vitro drug release. The size of the hydrogel was found to nanorange. The integrity of 5-ASA in the release fraction was assessed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The CS-Ac-PAMAM hydrogel was developed based on the modulation of ratio show promise as a system for controlled delivery of drug.