Synthesis and characterization of both enantiomers of trans-1,2-di-(2-hydroxy-2-propyl)-cyclobutane

✍ Scribed by Frank W. Curtius; Hans-Dieter Scharf

• Book ID: 103977663
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 304 KB
• Volume: 7
• Category: Article
• ISSN: 0957-4166
• DOI: 10.1016/0957-4166(96)00386-2

✦ Synopsis

Both enantiomers of the title compound are synthesized for the first time in four steps including a [2+2]-photocycloaddition to build up the cyclobutane backbone and a cerium supported reductive permethylation. During the cerium supported process a complete and selective change in the configuration of the cyclobutane ring takes place. The substituents are transformed from the cisto the trans-geometry.