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Synthesis and characterization of biodegradable and biocompatible amphiphilic block copolymers bearing pendant amino acid residues

✍ Scribed by Zhiguo Hu; Xiaoshan Fan; Huajie Wang; Jianji Wang

Book ID
104087949
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
554 KB
Volume
50
Category
Article
ISSN
0032-3861

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✦ Synopsis

Polylactide (PLA)-based biodegradable and biocompatible amphiphilic block copolymers bearing pendant amino acid residues were synthesized through a relatively easy and efficient way. The composition and structure of these copolymers were characterized by gel permeation chromatography (GPC) and 1 H nuclear magnetic resonance ( 1 H NMR) spectroscopy. The self-assembly behavior of the copolymers was investigated by fluorescence (FL), dynamic light scattering (DLS), and transmission electron microscope (TEM). It was shown that aggregates less than 100 nm in average size were formed by these copolymers, which changed from micelles to vesicles with the variation of the block length. In addition, the in vitro cytotoxicity of these copolymers was determined and compared with that of PEO-b-PLA in the presence of Bel-7402 cells. The result suggested that the block copolymers PAGE/cys-b-PLA exhibited better biocompatibility. Therefore, these PLA-based copolymers are expected to find promising applications in drug delivery or tissue engineering.

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