𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Characterization of Amphiphilic Biodegradable Copolymer, Poly(aspartic acid-co-lactic acid)

✍ Scribed by Hosei Shinoda; Yukiko Asou; Akio Suetsugu; Kimiko Tanaka

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
204 KB
Volume
3
Category
Article
ISSN
1616-5187

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An amphiphilic biodegradable polymer, poly(aspartic acid‐co‐lactic acid) (PAL), was synthesized by simply heating a mixture of aspartic acid (Asp) and L‐lactide without additional catalysts or solvents. The unique branched architecture comprising succinimide units and lactic acid units was confirmed by IR and NMR spectroscopy. A copolymer of sodium aspartate and lactic acid (PALNa) was prepared by reacting PAL with an aqueous sodium hydroxide solution. The PAL was soluble in many organic solvents, while the PALNa was soluble in methanol and water. The hydrolytic degradation behavior of PAL varied with the copolymer composition. A higher Asp content resulted in a faster molecular weight decrease, and introducing glycolic acid units accelerated the degradation rate.

Microphotograph of microsphere of PAL‐1/5.

magnified imageMicrophotograph of microsphere of PAL‐1/5.

📜 SIMILAR VOLUMES

Synthesis and characterization of amphip
Synthesis and characterization of amphiphilic biodegradable poly(glutamic acid-co-lactic acid-co-glycolic acid) by direct polycondensation
✍ Dedai Lu; Zongli Ren; Tianhong Zhou; Shoufeng Wang; Ziqiang Lei 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB 👁 1 views

## Abstract Poly(glutamic acid‐__co__‐lactic acid‐__co__‐glycolic acid) (PGLG), an amphiphilic biodegradable copolymer, was synthesized by simply heating a mixture of L‐glutamic acid (Glu), DL‐lactic acid, and glycolic acid with the present of stannous chloride. The unique branched architecture com

Synthesis of biodegradable material poly
Synthesis of biodegradable material poly(lactic acid-co-aspartic acid) via direct melt polycondensation and its characterization
✍ Rui-Rong Ye; Zhao-Yang Wang; Qun-Fang Wang; Kai Yang; Shi-He Luo 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB 👁 2 views

## Abstract Directly starting from L‐lactic acid (LA) and L‐aspartic acid (Asp), biodegradable material poly(lactic acid‐__co__‐aspartic acid) [P(LA‐__co__‐Asp)] was synthesized via melt polycondensation. The synthetic conditions, including type and dosage of catalyst, temperature, and time of copo

Synthesis and characterization of biodeg
Synthesis and characterization of biodegradable poly(L-aspartic acid-co-PEG)
✍ Chee-Youb Won; Chih-Chang Chu; Jong Doo Lee 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB 👁 2 views

The melt polycondensation reaction of the prepolymer prepared from N-(benzyloxycarbonyl)-L-aspartic acid anhydride (N-CBz-L-aspartic acid anhydride) and low molecular weight poly(ethylene glycol) (PEG) using titanium isopropoxide (TIP) as a catalyst produced the new biodegradable poly(L-aspartic aci

Synthesis and characterization of poly(d
Synthesis and characterization of poly(dimer acid–brassylic acid) copolymer and poly(dimer acid–pentadecandioic acid) copolymer
✍ Wen-xun Guo; Kai-xun Huang 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 128 KB 👁 1 views

## Abstract Poly(dimer acid–brassylic acid) [P(DA–BA)] copolymers and poly(dimer acid–pentadecandioic acid) [P(DA–PA)] copolymers were prepared by melt polycondensation of the corresponding mixed anhydride prepolymers. The copolymers were characterized by Fourier transform infrared (FTIR), gel perm