𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and characterization of amino protected peptides derived from amino-α- hydroxyiminophosphonates

✍ Scribed by Eli Breuer; Muhammad Safadi; Michael Chorev; Adam Vineze; Peter Bel

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
408 KB
Volume
47
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

Diisopropyl 2-amino-l-hydroxyiminoethylphosphonate (2_a), derived from glycine, and diisopropyl 4-amino-l-hydroxyiminobutylphosphonate (2__~), derived from GABA, were reacted with Boc-L-Phe-OH by the mixed anhydride method to yield novel peptide analogs diisopropyl 2-(t-Boc-L-Phe)amino-l-hydroxyiminoethylphosphonate (3__a) and diisopropyl 4-(t-Boc-L-Phe)amino-l-hydroxyiminobutylphosphonate (3__~). Diisopropyl 3-amino-1--hydroxyiminopropylphosphonate (L~), derived from #-Ala, and diisopropyl 2-amino-l-hydroxyiminopropylphosphonate (Ld_), derived from DL-AIa, were reacted with Boc-DL--Ala-OH by the mixed anhydride method to give peptide analogs diisopropyl 3-(t-Boc--L-Ala)amino-l-hydroxyiminopropylphosphonate (4__b) an¢ di~opropyl 2-(t-Boc-L-Ala)amino--l-hydroxyiminopropylphosphonate (4d) respectively. H, P NMR and FAB Mass spectra of the peptide analogs are reported.

📜 SIMILAR VOLUMES

Synthesis of thiazole amino-acids derive
Synthesis of thiazole amino-acids derived from natural peptides
✍ G.W. Kenner; R.C. Sheppard; C.E. Stehr 📂 Article 📅 1960 🏛 Elsevier Science 🌐 French ⚖ 136 KB

IN connexion with our studies on the antibiotic, Thiostrepton,' we have prepared a number of 2-(a-aminoalkyl)-thiazole-4-carboxylic acids (I, R=H, Me, Et end CHMe2). Since thiazole structures have been advanced for degradation products of other peptide antibiotics, 2,j a brief account of our results