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Synthesis and characterization of a series of carbamate-linked cationic lipids for gene delivery

✍ Scribed by Dongliang Liu; ianjun Hu; Weihong Qiao; Zongshi Li; Shubiao Zhan; Lvbo Cheng

Book ID
107487582
Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
619 KB
Volume
40
Category
Article
ISSN
0024-4201

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Reaction of 5'-0-dimethoxytritylthymidine with l,l'-carbonyldiimidazole gave the 3'-0-carbonylimidazolide, which was condensed in high yield with 5'-amino-5'-deoxythymidine to produce a dinucleoside containing a 3'-0-5'-N-carbamoyl linkage. Four repetitions of carbonyl imidazolide formation and con