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Synthesis and characterization of a novel calcium-selective chelator

โœ Scribed by Alison McCurdy; Amber M Kawaoka; Holly Thai; Sylvia C Yoon


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
96 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A calcium-selective photochromic chelator to study the effects of physiological [Ca 2+ ] oscillations on proteins in vitro or in vivo has been designed. The novel 2,2%-spirobi[2H-1-benzopyran] derivative 1 has been synthesized and the ion complexation properties of 1 with Mg 2+ , Ca 2+ , and Sr 2+ in aqueous buffered solution have been investigated. The chelator 1 shows modest selectivity for calcium ion (K 11 =6720 M -1 ) over magnesium ion (K 11 =564 M -1 ) by 1 H NMR titration.


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