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Synthesis and Characterization of 5-Fluorouracil and Polyethylene Glycol Esters as Prodrugs

โœ Scribed by Li, Cheng Wu; Li, Gang; Zuo, Ji Cheng


Book ID
120425162
Publisher
Trans Tech Publications, Ltd.
Year
2011
Tongue
English
Weight
259 KB
Volume
287-290
Category
Article
ISSN
1662-8958

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N-Nicotinyl-2-(5-ยฏuorouracil-1-yl)-D,L-glycine (NFG) and N-isonicotinyl-2-(5-ยฏuorouracil-1-yl)-D,L-glycine (INFG) were synthesized as colon-speciยฎc prodrugs of 5-ยฏuorouracil (5-FU). As N-aromatic acyl amides of glycine, they are expected to be stable in the upper intestine and delivered to the colon