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Synthesis and catalytic activity of poly-L-histidyl-L-aspartyl-L-seryl-glycine

✍ Scribed by A. N. Sarwal; E. O. Adigun; R. A. Stephani; A. Kapoor

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 483 KB
Volume: 71
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600711217

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✦ Synopsis

Poly(His-Asp-Ser-Gly) was synthesized from the fully protected tetrapeptide active ester hydrochloride, which was prepared by stepwise coupling, using pentachlorophenyl ester and mixed anhydride methods. Complete deprotection of the protected tetrapeptide polymer was achieved by using 90% trifluoroacetic acid. The free polymer was dialyzed for 24 hr using a membrane (which retains molecules with molecular weights >5000). The catalytic activity wits determined by studying the hydrolysis of p-nitrophenyl acetate in 0.2 M phosphate buffer (pH 7.4) at 37". The catalytic coefficient of the dialyzed polymer was found to be 138 liters/mole/min.

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