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Synthesis and cardiotonic activity of furo[3,4-b]- and difuro[3,4-b,3,4-e]pyridines

✍ Scribed by I. P. Skrastin'sh; R. O. Vitolinya; V. V. Kastron; G. Ya. Dubur


Book ID
112713608
Publisher
Springer
Year
1995
Tongue
English
Weight
216 KB
Volume
29
Category
Article
ISSN
0091-150X

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## Abstract A simple one‐step synthesis of 2‐amino‐4‐aryl‐5‐oxo‐4__H__‐furo[3,4‐__b__]pyran‐3‐carbonitriles 7 is described. It involves reaction of 2,4(3__H__,5__H__)‐furandione (β‐tetronic acid) (5) with arylmethylenemalononitriles 4 in basic medium. Some substituent effects are noted and the assi