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Synthesis and Calcium Channel Blocking Activity of 4-Indolyl-1,4-dihydropyridines

✍ Scribed by Rodolfo Lavilla; Teresa Gotsens; M.Carmen Santano; Joan Bosch; Antoni Camins; Noemi Arnau; Elena Escubedo; Jorge Camarasa; Merce Pallas

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 229 KB
Volume: 25
Category: Article
ISSN: 0045-2068
DOI: 10.1006/bioo.1997.1059

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✦ Synopsis

A series of indolyldihydropyridines has been designed, synthesized, and evaluated in order to show the effect of the indole moiety and the role of the methyl groups at the 2 and 6 positions of the dihydropyridine ring in the calcium channel blocking activity. The results seem to show that these groups constitute a critical structural requirement for the pharmacological action of these compounds.

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