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Synthesis and calcium channel antagonist activity of novel 1,4-dihydropyridine derivatives possessing 4-pyrone moieties

✍ Scribed by Aziz Shahrisa; Ramin Miri; Somayeh Esmati; Mahnaz Saraei; Ahmad Reza Mehdipour; Maryam Sharifi

Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
336 KB
Volume
21
Category
Article
ISSN
1054-2523

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Synthesis and Calcium Channel Blocking A
Synthesis and Calcium Channel Blocking Activity of 4-Indolyl-1,4-dihydropyridines
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A series of indolyldihydropyridines has been designed, synthesized, and evaluated in order to show the effect of the indole moiety and the role of the methyl groups at the 2 and 6 positions of the dihydropyridine ring in the calcium channel blocking activity. The results seem to show that these grou