Synthesis and Bridgehead Reactions of 9-Substituted 5,6,7,8,9,10-Hexahydro-5,9-Methanopyrimido[4,5-b]azocin-4(3H)-ones
โ Scribed by C. Taylor, Edward; Bhatia, Beena
- Book ID
- 127026110
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 2003
- Tongue
- English
- Weight
- 393 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0385-5414
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๐ SIMILAR VOLUMES
Unexpected and Facile Bridgehead Substitution in 5,6,7,8,9, azocin-4(3H)-ones. -A method for the reductive removal of the bridgehead hydroxyl group in title compound (III) is developed. A bridgehead imine intermediate is proposed to be involved in the formation of thioether (VII). The protected tr
## Synthesis of 2,4- 6,7,8,9,9methanopyrimido[4,azocine. -Optimization of direct annulation of triaminopyrimidine (I) with cyclohexenone (II) is achieved using acetic acid as solvent in a screw-capped pressure tube that is heated at 120 โข C for 18 hours. Compound (VII) as prototype, its derivative