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Synthesis and Biological Properties of L-Arginyl-L-Prolyl-L-Prolyl-Glycyl-L-Phenylalanyl-L-Seryl-L-Phenylalanyl-L-Arginine, an Octapeptide related to Bradykinin

✍ Scribed by NICOLAIDES, E. D.; DEWALD, H. A.; SHORLEY, PATRICIA G.; COLLIER, H. O. J.


Book ID
109610780
Publisher
Nature Publishing Group
Year
1960
Tongue
English
Weight
223 KB
Volume
187
Category
Article
ISSN
0028-0836

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Synthèse de la L-arginyl-L-prolyl-L-prol
✍ R. A. Boissonnas; St. Guttmann; P.-A. Jaquenoud 📂 Article 📅 1960 🏛 John Wiley and Sons 🌐 German ⚖ 534 KB

Pentaethylbenzoic acid was produced in good yield bv saponification of the amide with 100% phosphoric acid, while under the same conditions pentamethylbenzamide was completely decarboxylated to pentamethylbenzene. The cyclisation of o-(pentaethylbenzoy1)-benzoic acid yielded an alkaline soluble, ye

Synthèse de la L-arginyl-L-prolyl-L-prol
✍ R. A. Boissonnas; St. Guttmann; P.-A. Jaquenoud 📂 Article 📅 1960 🏛 John Wiley and Sons 🌐 German ⚖ 748 KB

## Abstract The synthesis of a nonapeptide exhibiting bradykinin‐like properties is described. Condensation of CBO‐(nitro)Arg‐Pro‐OH with H‐Pro‐Gly‐NHNH‐CTO and selective splitting of the CTO‐group yielded CBO‐(nitro)Arg‐Pro‐Pro‐Gly‐NHNH~2~. CBO‐Phe‐ Ser‐N~2~ was condensed with H‐Pro‐Phe‐(nitro)Arg