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Synthesis and biological evaluation of the binding of dopamine D2/D3 receptor agonist, (R,S)-5-hydroxy-2-(N-propyl-N-(5′-18F-fluoropentyl)aminotetralin (18F-5-OH-FPPAT) in rodents and nonhuman primates

✍ Scribed by Bingzhi Shi; Tanjore K Narayanan; Bradley T Christian; Sankha Chattopadhyay; Jogeshwar Mukherjee

Book ID
116798724
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
299 KB
Volume
31
Category
Article
ISSN
0969-8051

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In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist 11C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate
✍ Jogeshwar Mukherjee; Tanjore K. Narayanan; Bradley T. Christian; Bingzhi Shi; Ke 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 3 views

The in vitro autoradiographic binding characteristics as well as in vivo imaging characteristics of a dopamine D2 receptor agonist, (R,S)-2-(N-propyl-N-1Ј-11 Cpropyl)amino-5-hydroxytetralin ( 11 C-5-OH-DPAT), were studied. In 3 H-spiperone assays using rat striata, 5-OH-DPAT exhibited an affinity of