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Synthesis and biological evaluation of taxinine analogues as orally active multidrug resistance reversal agents in cancer

✍ Scribed by Xin Zhao; Jun Gu; Dali Yin; Xiaoguang Chen


Book ID
108073401
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
269 KB
Volume
14
Category
Article
ISSN
0960-894X

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✍ Meng Huang; Xin Zhao; Meng Zhang; Jun Gu; Xiaoguang Chen; Dali Yin πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 609 KB

Two types of sinenxan A derivatives with different side chains at C-5 were synthesized and evaluated for their in vitro multidrug resistant reversal activities. Several derivatives exhibited better activities than the positive control verapamil. The structure-activity relationships of these derivati