Synthesis and structure–activity relationships of sinenxan A derivatives as multidrug resistance reversal agents

✍ Scribed by Meng Huang; Xin Zhao; Meng Zhang; Jun Gu; Xiaoguang Chen; Dali Yin

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 609 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.07.099

✦ Synopsis

Two types of sinenxan A derivatives with different side chains at C-5 were synthesized and evaluated for their in vitro multidrug resistant reversal activities. Several derivatives exhibited better activities than the positive control verapamil. The structure-activity relationships of these derivatives suggested that a carbonyl group at C-13 and the length of side chain at C-5 are important for the activity.