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Synthesis and Biological Evaluation of Substituted Flavones as Gastroprotective Agents

โœ Scribed by Ares, Jeffrey J.; Outt, Pamela E.; Randall, Jared L.; Murray, Peter D.; Weisshaar, Pamela S.; O'Brien, Linda M.; Ems, Beth L.; Kakodkar, Sunil V.; Kelm, Gary R.


Book ID
119955964
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
936 KB
Volume
38
Category
Article
ISSN
0022-2623

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Synthesis and biological evaluation of f
โœ Jeffrey J. Ares; Pamela E. Outt; Jared L. Randall; Jeffrey N. Johnston; Peter D. ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 208 KB

Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminat