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Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-n-oxide as selective glycine antagonists

✍ Scribed by Alfredo Cugola; Daniele Donati; M. Guarneri; Fabrizio Micheli; Andrea Missio; Angelo Pecunioso; Angelo Reggiani; G. Tarzia; V. Zanirato

Book ID
104364638
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
217 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

Pyrido [2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor.

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1H and 13C NMR Spectra of Pyrido[2,3-b]p
1H and 13C NMR Spectra of Pyrido[2,3-b]pyrazines and Pyrido[2,3-b]pyrazine-N-oxides
✍ S. PROVERA; C. MARCHIORO; S. DAVAILLI; N. CASE πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 160 KB πŸ‘ 1 views

1H and 13C NMR spectral data for several pyridoÍ2,3-b Γ‹pyrazines and pyridoÍ2,3-b Γ‹pyrazine-N -oxides are reported. The chemical shift assignments were based on 1D-NOE, gradient HSQC and gradient HMQC experiments for some model compounds. 1997 < by John Wiley & Sons, Ltd.