✦ LIBER ✦

Synthesis and biological evaluation of oxoindolin-3-ylidene ethyl benzothiohydrazides as non-peptide TPO mimics

✍ Scribed by Peng Cho Tang; He Jun Lu; Yi Qian Chen; Sheng Lan Wang; Hao Zheng; Li Wang

Book ID: 104004648
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 250 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.07.040

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✦ Synopsis

A novel series of oxoindolin-3-ylidene ethyl benzohydrazides were designed, synthesized, and identified as small molecule agonists of thrombopoietin (TPO) receptor c-mpl. Sulfur-oxygen exchange in oxoindolin-3-ylidene ethyl benzohydrazides was found to improve their agonistic activities. Several oxoindolin-3-ylidene ethyl benzothiohydrazides have been identified as full agonists of c-mpl.

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