A novel series of oxoindolin-3-ylidene ethyl benzohydrazides were designed, synthesized, and identified as small molecule agonists of thrombopoietin (TPO) receptor c-mpl. Sulfur-oxygen exchange in oxoindolin-3-ylidene ethyl benzohydrazides was found to improve their agonistic activities. Several oxo
1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics
β Scribed by Bock, Victoria D.; Speijer, Dave; Hiemstra, Henk; van Maarseveen, Jan H.
- Book ID
- 118742325
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 166 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B616751A
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## Abstract magnified image 1,3 Dipolar cycloaddition of Fmocβamino azides and acetylenic amides produces under solvent free irradiation a mixture of 1,4 or 1,5 substituted [1,2,3]βtriazoles. The presence of copper (I) iodide, plays a central role on regioselectivity. Four Fmocβamino azides charac