Synthesis and biological evaluation of novel conjugated coumarin-thiazole systems

✍ Scribed by Franco Chimenti; Simone Carradori; Daniela Secci; Adriana Bolasco; Paola Chimenti; Arianna Granese; Bruna Bizzarri

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2009
• Tongue: English
• Weight: 75 KB
• Volume: 46
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.110

✦ Synopsis

Abstract

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Seven new 2,4‐disubstituted thiazoles have been synthesized by Hantzsch condensation and assayed for several biological activities for a preliminary screening. They have been fully characterized by elemental analysis, UV–Vis spectroscopy, TG‐DTA, IR, and ^1^H NMR as well. These structures display different pharmacological (antimicrobic activity, citotoxicity, and hMAO inhibition) and industrial properties (complete transparency in the region between 465–800 nm and high thermal stability) varying on their substituents and could be considered as good lead compounds for further developments. J. Heterocyclic Chem., (2009).