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Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors

โœ Scribed by Afshin Zarghi; Razieh Ghodsi; Ebrahim Azizi; Bahram Daraie; Mehdi Hedayati; Orkideh G. Dadrass


Book ID
108072659
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
345 KB
Volume
17
Category
Article
ISSN
0968-0896

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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical