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Synthesis and biological evaluation of leucine enkephalin turn mimetics

✍ Scribed by Blomberg, David; Kreye, Paul; Fowler, Chris; Brickmann, Kay; Kihlberg, Jan


Book ID
119947368
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
283 KB
Volume
4
Category
Article
ISSN
1477-0520

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πŸ“œ SIMILAR VOLUMES


Synthesis of a novel Ξ²-turn mimetic and
✍ Paul Kreye; Jan Kihlberg πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 223 KB

A conformationaily restricted 13-turn mimetic, in which an ethylene bridge replaces the intramolecular hydrogen bond between residues i and i + 3 of 13-turns, has been prepared and incorporated in Leu-enkephalin. Amino acids and a-bromoaeids were used as building blocks in the synthesis of the mimet