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Synthesis and Biological Evaluation of Azido- and Aziridino-hydroxyl-β-lactams Through Stereo- and Regioselective Epoxide Ring Opening.

✍ Scribed by Fides Benfatti; Giuliana Cardillo; Luca Gentilucci; Rossana Perciaccante; Alessandra Tolomelli; Alberico Catapano


Publisher
John Wiley and Sons
Year
2007
Weight
30 KB
Volume
38
Category
Article
ISSN
0931-7597

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Abstract

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Synthesis of Four-Membered Ring Spiro-β-
✍ Fides Benfatti; Giuliana Cardillo; Luca Gentilucci; Alessandra Tolomelli 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB

## Abstract A variety of hydroxy epoxides have been obtained from well defined hydroxy‐alkenyl derivatives. Their subsequent intramolecular ring‐opening allowed unprecedented classes of spiro‐lactams to be obtained. The effect of the epoxide stereochemistry and of the reaction temperature on the re