Synthesis and Biological Evaluation of Andrographolide C-Glycoside Derivatives as α-Glycosidase Inhibitors
β Scribed by Lin Yan; Haiwei Xu; Fengwu Liu; Jin Zhao; Hongmin Liu
- Book ID
- 112060387
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 398 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0256-7660
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The glucoseβ, mannoseβ, and galactoseβderived spirocyclic cyclopropylammonium chlorides **1a**β**1d, 2a**β**2d** and **3a**β**3d** were prepared as potential glycosidase inhibitors. Cyclopropanation of the diazirine **5** with ethyl acrylate led in 71% yield to a 4β:β5β:β1β:β20 mixture
## Dedicated to Professor Wolfgang Steglich on the occasion of his 70th birthday The spirodiaziridines 6 and 9, potential inhibitors of aand b-glucosidases, were prepared from the validoxylamine A-derived cyclohexanone 5. The trimethylsilyl protecting groups of 5 are crucial for the formation of 6