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Synthesis and biological evaluation of an electronically activated isooxacephem

✍ Scribed by Gholam H. Hakimelahi; Shwu-Chen Tsay; Hsi-Hwa Tso; Zahra Ramezani; Jih Ru Hwu

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 344 KB
Volume: 4
Category: Article
ISSN: 0968-0896
DOI: 10.1016/0968-0896(96)00131-9

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✦ Synopsis

New isooxacephem (+)-3-ethyl 2-hydrogen (6RS,7RS)- 8-oxo-7-(phenylacetamido)-4-oxa-l-azabicyclo[4.2.0] 1) in six steps. This bicyclic 13-1actam was found to possess notable biological activities against several pathogenic microorganisms in vitro, including Staphylococcus aureus 95, S. aureus FDA 209P, Escherichia coli ATCC 39188, Salmonella typhi O-901, Pseudomonas aeruginosa 18S-H, P. aeruginosa 1101-75, and Klebsiella pneumoniae NCTC 418. The electronic activation of the [3-1actam moiety by an ester group plays a prominent role in the biological activity of this novel isooxacephem.

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