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Synthesis and Biological Activity Evaluation Studies on Novel Isoxazolidines.

โœ Scribed by Virinder S. Parmar; et al. et al.


Publisher
John Wiley and Sons
Year
2005
Weight
28 KB
Volume
36
Category
Article
ISSN
0931-7597

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Synthesis and biological evaluation of n
โœ Bing Zhou; Zehong Miao; Gang Deng; Jian Ding; Yaxi Yang; Huijin Feng; Yuanchao L ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 672 KB

Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-ฮฒ-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest