✦ LIBER ✦

Synthesis and Biological Evaluation of a Novel Series of “Ortho-Nitrated” Inhibitors of Catechol- O -methyltransferase

✍ Scribed by Learmonth, David A.; Bonifácio, Maria João; Soares-da-Silva, Patrício

Book ID: 120234588
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 162 KB
Volume: 48
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0580454

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis, Biological Evaluation, and Mo

Synthesis, Biological Evaluation, and Molecular Modeling Studies of a Novel, Peripherally Selective Inhibitor of Catechol-O-methyltransferase

✍ Learmonth, David A.; Palma, P. Nuno; Vieira-Coelho, Maria A.; Soares-da-Silva, P 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 378 KB

Synthesis of some novel potent and selec

Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors

✍ Backstrom, Reijo; Honkanen, Erkki; Pippuri, Aino; Kairisalo, Pekka; Pystynen, Ja 📂 Article 📅 1989 🏛 American Chemical Society 🌐 English ⚖ 756 KB

Chemical Synthesis and Characterization

Chemical Synthesis and Characterization of Conjugates of a Novel Catechol- O -methyltransferase Inhibitor

✍ Learmonth, David A.; Freitas, Ana P. 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 122 KB

Synthesis and in Vitro Evaluation of Two

Synthesis and in Vitro Evaluation of Two Progressive Series of Bifunctional Polyhydroxybenzamide Catechol- O -methyltransferase Inhibitors

✍ Brevitt, Sharon E.; Tan, Eng Wui 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 154 KB

Synthesis and Biological Evaluation of P

Synthesis and Biological Evaluation of Potent Bisubstrate Inhibitors of the Enzyme Catechol O-Methyltransferase (COMT) Lacking a Nitro Group

✍ Ralph Paulini; Christian Lerner; François Diederich; Roland Jakob-Roetne; Gerhar 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 431 KB

Inhibition of the enzyme catechol O-methyltransferase (COMT) represents a viable strategy for regulation of the catabolism of catecholamine neurotransmitters or their precursors, and is of considerable interest in the therapy of Parkinsons disease. Herein, we report the development of a new generati

Convenient Synthesis of Tolcapone, a Sel

Convenient Synthesis of Tolcapone, a Selective Catechol‐ O ‐methyltransferase Inhibitor

✍ Manikumar, Govindarajan; Jin, Chunyang; Rehder, Kenneth S. 📂 Article 📅 2008 🏛 Taylor and Francis Group 🌐 English ⚖ 111 KB