Synthesis and Biological Evaluation of P
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Ralph Paulini; Christian Lerner; François Diederich; Roland Jakob-Roetne; Gerhar
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Article
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2006
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John Wiley and Sons
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German
⚖ 431 KB
Inhibition of the enzyme catechol O-methyltransferase (COMT) represents a viable strategy for regulation of the catabolism of catecholamine neurotransmitters or their precursors, and is of considerable interest in the therapy of Parkinsons disease. Herein, we report the development of a new generati