Synthesis and biological evaluation of a novel anti-malarial lead
โ Scribed by Nicholas L. Hammond; Seoung-ryoung Choi; Paulo Carvalho; Hua Liu; Shabana Khan; Mitchell A. Avery
- Book ID
- 105771085
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 335 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1054-2523
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GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum, the parasite primarily responsible for the mortality associated with malaria worldwide. GW844520 is fully active against the parasite including resistance isolates, showin