The synthesis and glycine-NMDA binding activity of a series of quinazoline-2-carboxylic acids 1 and quinazoline-2,4-diones 2, containing all the essential and optional pharmacophoric descriptors required by a putative glycine antagonist model, are reported. The binding results show that only three o
Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5- c ]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists
✍ Scribed by Varano, Flavia; Catarzi, Daniela; Colotta, Vittoria; Filacchioni, Guido; Galli, Alessandro; Costagli, Chiara; Carlà, Vincenzo
- Book ID
- 121288160
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 112 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2623
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Synthesis and Biological Evaluation of a Series of Quinazoline-2carboxylic Acids and Quinazoline-2,4-diones as Glycine-NMDA Antagonists: A Pharmacophore Model Based Approach. -Although the compounds studied contain all features required by the antagonist pharmacophore model, they only show poor aff
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