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Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity

โœ Scribed by Akhter, Mymoona; Akhter, Nayeema; Alam, M. M.; Zaman, M. S.; Saha, Rikta; Kumar, A.


Book ID
120170468
Publisher
Informa plc
Year
2011
Tongue
English
Weight
708 KB
Volume
26
Category
Article
ISSN
1475-6366

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โœ Yisheng Lai; Lin Ma; Wenxing Huang; Xing Yu; Yihua Zhang; Hui Ji; Jide Tian ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 424 KB

Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I