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Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones

✍ Scribed by Schmidhammer, Helmut; Aeppli, Lislott; Atwell, Louise; Fritsch, Florian; Jacobson, Arthur E.; Nebuchla, Michaela; Sperk, Guenther


Book ID
118017115
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
709 KB
Volume
27
Category
Article
ISSN
0022-2623

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Synthesis and Biological Evaluation of 1
✍ Helmut Schmidhammer; Willy P. Burkard; Lislott Eggstein-Aeppli πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 German βš– 522 KB

The N-(cyclobutylmethy1)morphinans 12, 19, 20, 21, 27, and 29 and the N-(2-cyanoethyl) analogue 33 were prepared from different precursors. Pharmacological evaluation (e.g. opioid receptor binding assays, acetic-acid writhing test, hot-plate assay) points to a partial opioid agonism of compounds 12,