Synthesis and Biological Evaluation of 1
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Helmut Schmidhammer; Willy P. Burkard; Lislott Eggstein-Aeppli
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Article
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1989
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John Wiley and Sons
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German
β 522 KB
The N-(cyclobutylmethy1)morphinans 12, 19, 20, 21, 27, and 29 and the N-(2-cyanoethyl) analogue 33 were prepared from different precursors. Pharmacological evaluation (e.g. opioid receptor binding assays, acetic-acid writhing test, hot-plate assay) points to a partial opioid agonism of compounds 12,