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Synthesis and Biological Evaluation of 14-Alkoxymorphinans Part 4 opioid agonists and partial opioid agonists in a series of N-(cyclobutylmethyl)-14-methoxymorphinan-6-ones

✍ Scribed by Helmut Schmidhammer; Willy P. Burkard; Lislott Eggstein-Aeppli

Publisher: John Wiley and Sons
Year: 1989
Tongue: German
Weight: 522 KB
Volume: 72
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19890720607

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✦ Synopsis

The N-(cyclobutylmethy1)morphinans 12, 19, 20, 21, 27, and 29 and the N-(2-cyanoethyl) analogue 33 were prepared from different precursors. Pharmacological evaluation (e.g. opioid receptor binding assays, acetic-acid writhing test, hot-plate assay) points to a partial opioid agonism of compounds 12, 27, 29, and 33, and to full opioid agonism of compounds 1P-21. ') Part 3: 111.

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