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Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter

✍ Scribed by Jonathan McConathy; Michael J. Owens; Clinton D. Kilts; Eugene J. Malveaux; Vernon M. Camp; John R. Votaw; Charles B. Nemeroff; Mark M. Goodman

Book ID
116798700
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
278 KB
Volume
31
Category
Article
ISSN
0969-8051

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## Abstract __Introduction:__ (__R__)‐3‐(2‐(methylthio)phenoxy)‐__N__‐methyl‐3‐phenylpropan‐1‐amine [(__R__)–thionisoxetine; **1**] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label **1** with carbon‐11 (__t__~1/2~ = 20.4 min) for evaluation as a radioligand for imagi