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Synthesis and Biological Effects of New 3-Alkylamino-4H-1,2,4-Benzothiadiazine 1,1-Dioxides on Insulin-secreting Cells

✍ Scribed by F. SOMERS; P. DE TULLIO; S. BOVERIE; J. M. DOGNÉ; X. DE LEVAL; M. -H. ANTOINE; P. LEBRUN; B. PIROTTE


Book ID
111769915
Publisher
Pharmaceutical Press
Year
2000
Tongue
English
Weight
144 KB
Volume
6
Category
Article
ISSN
2042-7158

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Efficient synthesis of 4,4-disubstituted
✍ Esteban Domı́nguez; Jesús de Blas; Miriam del Prado; M.Teresa Aranda; M.Carmen C 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 63 KB

A simple method for the preparation of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2dioxides is described. Treatment of N-sulfonyl ketimines 2 and 3 with different carbon nucleophiles afforded the corresponding of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides 1 i