Synthesis and biological activity of some nitrogen-containing analogs of emodin
β Scribed by A. N. Pribytkova
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 181 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0009-3130
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π SIMILAR VOLUMES
2-adamantanole was the protecting group of the aspartate 13-COOH moiety during the peptide synthesis and survived the final peptide cleavage and deprotection carried out under controlled conditions. MEN 10586 showed an agonist activity comparable to that of the parent compound MEN 10210 at NK~ and N
Structural assignments for the various synthetic intermediates were confirmed by infrared, proton magnetic resonance and mass spectroscopy on chromatographically homogeneous samples. This cycloaddition probably involves the intermediacy of a triazoline rather than a nitrene. See A.L. Logothetis, J