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Synthesis and biological activity of some lipophilic derivatives of 1-thio-muramoyl-l-alanyl-d-isoglutamine

✍ Scribed by Akira Hasegawa; Eiji Seki; Yuichi Hioki; Makoto Kiso; Ichiro Azuma

Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 686 KB
Volume: 131
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(84)85404-x

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✦ Synopsis

2-N-Octadecanoyl derivatives of 1-S-acetyl-, 1-S-octadecanoyl-, and of 6-O-octadecanoyl-1-S-octadecanoyl-1-thiomuramoyl-L-ala nyl-D-isoglutamine were synthesized from benzyl 3,4,6-tri-O-acetyl-2-deoxy-2-(octadecanoylamino)-beta-D-glucopy ran oside. Their immunoadjuvant activities were examined in guinea-pigs.

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