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SYNTHESIS AND BIOLOGICAL ACTIVITY OF N -AROYL- N ′-SUBSTITUTED THIOUREA DERIVATIVES

✍ Scribed by Zhang, You-Ming; Wei, Tai-Bao; Gao, Li-Ming

Book ID
120160927
Publisher
Taylor and Francis Group
Year
2001
Tongue
English
Weight
142 KB
Volume
31
Category
Article
ISSN
0039-7911

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Starting from amino(di)azines and 2-chloro-6-methyliso(thio)cyanate a series of aryl-substituted urea and thiourea derivatives was prepared and screened as potential antiepileptics. Among the new derivatives tested, only 2b and 3c exhibited adequate anticonvulsant effects, whereas 3d and 4d were fou