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Synthesis and biological activity of guanylhydrazones of 2- and 4-pyridine and 4-quinoline carboxaldehydes

✍ Scribed by William O. Foye; Bijan Almassian; Marc S. Eisenberg; Timothy J. Maher

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
313 KB
Volume
79
Category
Article
ISSN
0022-3549

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✦ Synopsis

A series of guanylhydrazones derived from 2- and 4-pyridine and 4-quinoline carboxyaldehydes was synthesized from S-methylisothio-semicarbazide hydroiodide using known procedures. The compounds are analogous to anticancer and antiviral thiosemicarbazones, but several of the guanylhydrazones derived from 4-quinoline carboxaldehyde showed no activity against P388 lymphocytic leukemia in mice. Guanylhydrazones derived from all three heterocyclic aldehydes revealed significant blood pressure lowering effects in the rat, however.

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