Structureβactivity relationships of dyno
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Georg Schlechtingen; Robert N. DeHaven; Jeffrey D. Daubert; Joel Cassel; Murray
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Article
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2003
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Wiley (John Wiley & Sons)
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English
β 94 KB
π 2 views
Following up on the observation that the dynorphin analog [Pro(3)]Dyn A(1-11)-NH(2) 2 possesses high affinity and selectivity for the kappa opioid receptor, a number of related peptides were prepared and characterized by radioligand binding and [(35)S]GTPgammaS assays. While incorporation of 2-azeti