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Synthesis and biological activity of dynorphin-(1 - 13) and analogs substituted in positions 8 and 10

✍ Scribed by LEMAIRE, SIMON ;LAFRANCE, LUCIE ;DUMONT, MICHEL


Book ID
115098466
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
430 KB
Volume
27
Category
Article
ISSN
0367-8377

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Structure–activity relationships of dyno
✍ Georg Schlechtingen; Robert N. DeHaven; Jeffrey D. Daubert; Joel Cassel; Murray πŸ“‚ Article πŸ“… 2003 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 94 KB πŸ‘ 2 views

Following up on the observation that the dynorphin analog [Pro(3)]Dyn A(1-11)-NH(2) 2 possesses high affinity and selectivity for the kappa opioid receptor, a number of related peptides were prepared and characterized by radioligand binding and [(35)S]GTPgammaS assays. While incorporation of 2-azeti