๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis and Biological Activity of 2-Aminopurine Methylenecyclopropane Analogues of Nucleosides.

โœ Scribed by Ruifang Wang; Xinchao Chen; John C. Drach; Earl R. Kern; Jiri Zemlicka

Publisher
John Wiley and Sons
Year
2003
Weight
130 KB
Volume
34
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

โœฆ Synopsis

Synthesis and Biological Activity of 2-Aminopurine Methylenecyclopropane Analogues of Nucleosides. -Racemic 2-aminopurine methylenecyclopropane analogues such as (V) and (VI), as well as the (S)-enantiomer of compound (V) are synthesized and evaluated for their bioactivity. All the racemic compounds are found to be inactive against various virus species, while ((S)-(V)) inhibits replication of HSV-1, possesses moderate activity against VZV and it is a substrate for xanthine oxidase. -(

๐Ÿ“œ SIMILAR VOLUMES

Synthesis and Biological Activities of 2
Synthesis and Biological Activities of 2-Functionalized Purine Nucleosides.
โœ Vasu Nair; Bindu Bera; Earl R. Kern ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons โš– 195 KB ๐Ÿ‘ 1 views

Synthesis and Biological Activities of 2-Functionalized Purine Nucleosides. -New applications of synthetic methodologies in nucleoside chemistry are presented for the preparation of 2-functionalized purine ribonucleosides in good to excellent yields. The target molecules are designed as potential in