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Synthesis and Biological Activities of 2-Functionalized Purine Nucleosides.

✍ Scribed by Vasu Nair; Bindu Bera; Earl R. Kern

Publisher: John Wiley and Sons
Year: 2003
Weight: 195 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200333209

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✦ Synopsis

Synthesis and Biological Activities of 2-Functionalized Purine Nucleosides. -New applications of synthetic methodologies in nucleoside chemistry are presented for the preparation of 2-functionalized purine ribonucleosides in good to excellent yields. The target molecules are designed as potential inhibitors (as their monophosphates) of inosine monophosphate dehydrogenase (IMPDH) and representative inhibition data are reported. Antiviral data of the compounds are also described. -(

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