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Synthesis and biological activity evaluation of cytidine-5′-deoxy-5-fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates

✍ Scribed by Jhansi Rani, V.; Raghavendra, A.; Kishore, P.; Nanda Kumar, Y.; Hema Kumar, K.; Jagadeeswarareddy, K.

Book ID
119234037
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
619 KB
Volume
54
Category
Article
ISSN
0223-5234

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## Abstract The new amphiphilic dinucleoside phosphate, 2′‐deoxy‐5‐fluorouridylyl‐(3′→5′)‐2′‐deoxy‐5‐fluoro‐__N__^4^‐octadecylcytidine (4) was synthesized on a gram scale, using the phosphotriester method, starting from the cytostatic drug 2′‐deoxy‐5‐fluorouridine (5FdU) and 2′‐deoxy‐5‐fluoro‐__N__