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ChemInform Abstract: Synthesis and Biological Activity of O-Alkyl-3-N-aminoacyloxymethyl-5- fluoro-2′deoxyuridine Derivatives.

✍ Scribed by N. HARADA; M. HONGU; T. KAWAGUCHI; M. OHOHASHI; K. ODA; T. HASHIYAMA; K. TSUJIHARA

Book ID: 112040533
Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 27
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199647235

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Synthesis and Biological Activity of Bis(pivaloyloxymethyl) Ester of 2'-Azido-2'-deoxyuridine 5'-Monophosphate. -The title compound (III) which is the membrane-permeable prodrug of the phosphate (I), is evaluated with positive results for inhibition of cell growth with 60 tumor cell lines.