Synthesis and Biological Activities of Tricyclic Conformationally Restricted Tetrahydropyrido Annulated Furo[2,3- d ]pyrimidines as Inhibitors of Dihydrofolate Reductases 1
β Scribed by Gangjee, Aleem; Elzein, Elfatih; Queener, Sherry F.; McGuire, John J.
- Book ID
- 120888645
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 132 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Three previously undescribed dihydrofolate reductase (DHFR) inhibitors, N^Ξ±^β[4β[__N__β[(2,4βdiaminopyrrolo[2,3β__d__]pyrimidinβ5βyl)methyl]amino]benzoyl]β__N__^Ξ΄^βhemiphthaloylβLβornithine **(7)**, __N__^Ξ±^β [4β [__N__β[(2,4βdiaminothieno[2,3β__d__]pyrimidinβ5βyl)methyl]amino]benzoyl]β