The synthesis of LTF4 via the reaction of (+)-leukotrlene A4(LTA4), mett-il ester 1 with the protected glutamylcystelne 1 1s reported The leukotrienes LTC4, D4 and E4 are a recently dlscovered family of arachldonlc acid metabolltes which are thought to be involved in certain hypersensitlvlty reactl
β¦ LIBER β¦
Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone
β Scribed by D. Denis; S. Charleson; A. Rackham; T.R. Jones; A.W. Ford-Hutchinson; A. Lord; M. Cirino; Y. Girard; M. Larue; J. Rokach
- Book ID
- 119049337
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 720 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0090-6980
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A simple one-step preparation of the sulfones of Leukotriene Cq, D, and E, has been developed by the direct oxidation of the parent compounds. An alternative synthesis of these sulfones has also been carried out by reduction of an acetylenic precursor. Slow reacting substance of anaphylaxis (SRS-A)