Synthesis and biological activities of 2β-chloro-, 2β-fluoro-, and 2β-methoxy-1α,25-dihydroxyvitamin D3
✍ Scribed by Dietmar Scheddin; Hubert Mayer; Bruno Schönecker; Sabine Gliesing; Manfred Reichenbächer
- Book ID
- 117214033
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 340 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0039-128X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The reaction of [2-14C]-2 ,4-bis-O-(trimethylsilyl)uracil (2) with ~-~-acetyl-~-0-benzoyl-2-deoxy-2-fluoro-~-D-arabinofuranosyl bromide (3) yielded the 3-O-acety1-5-0-benzoyl nucleos e 4 which was hydrolyzed with methanolic ammonia to afford [ 2-feC]-T-( 2-deoxy-2fluoro-p-D-arabinofuranosy1)uracil (
We found a concise route to the Trost A-ring precursor enyne for synthesizing 2a-alkylated 1a,25-dihydroxyvitamin D 3 (1) from d-glucose. The enynes were coupled with the 20-epi-CD ring part to study the effect of the double modification of 2asubstitution and 20-epimerization upon biological activit